New insights into cerebellar dysfunction in patients with delusional disorder: A systematic review

Introduction The cerebellum has been implicated in cognitive, affective and motor functions, including emotion regulation, executive control sensorimotor processing. In schizophrenia, cerebellar dysfunction associated with treatment resistance clinical features. However, few studies have focused on delusional disorder (DD). Objectives Our main purpose was to review the evidence available abnormalities dysfunctions patients DD. Methods A systematic conducted through PubMed, Scopus ClinicalTrials.gov (inception-June 2022) according Preferred Reporting Items for Systematic Reviews Meta-analyses (PRISMA) directives. following search terms were used: OR AND (“delusional disorder” paranoia). Reference lists from included hand-checked find other potential relevant papers. Results Six a total of 119 retrieved records (PubMed: 52, Scopus: 66, ClinicalTrials.gov: 1). Study 1:Patients DD somatic type (n=14) presented decreased gray matter volume lobules compared healthy controls (HC) (n=32, left lobule VIIIa) non-somatic (n=18, V). Cerebellar volumes did not seem differ between HC 2:Abnormalities voluntary saccadic eye movements, linking frontal found (n=34) (n=40). 3: Abnormal smooth pursuit movements (n=15) (n=40) similar schizophrenia Case reports (n=3): Dandy-Walker variant (partial vermian hypoplasia), unruptured intracerebral aneurysm basilar artery, megacisterna magna. Conclusions deficits reported, particularly those presenting contents. Disclosure Interest None Declared